Low MPV

One of the terms encountered in blood test results, MPV (Mean Platelet Volume) refers to the average size of platelets. The MPV value is an important indicator to understand the size and functionality of platelets produced in the bone marrow. A low MPV indicates that platelets are smaller than normal, which may signal various health problems.

At A Life Health Group, we thoroughly address what low MPV means, its causes, and how it can be treated.

• Platelets: Cell fragments involved in blood clotting. They help stop bleeding in case of injury.
• MPV Value: Measures the size of platelets and provides information about platelet production in the bone marrow.
  • Normal MPV Values: Considered to be in the range of 7.5 - 12 femtoliters (fL).
  • Low MPV: A value below this range may indicate that platelets are small and functionally weak.

Low MPV may be a sign that there is a problem in your body. However, low MPV is not a disease by itself and should be evaluated together with other tests and symptoms. Some possible causes of low MPV are:

• Anemia
• Bone marrow disorders
• Vitamin B12 deficiency
• Medication use
• Liver disease
• Immune system disorders

There are many factors and health issues that can cause low MPV. Here are the main causes:

• Platelets are produced in the bone marrow. Insufficient platelet production in the bone marrow can lead to a decrease in MPV value.
• Example: Diseases such as aplastic anemia, leukemia.

• Iron deficiency negatively affects the production of blood cells. It can cause changes in platelet production and size.

• Especially viral infections can cause a decrease in platelet production, leading to low MPV.

• Low MPV can be seen in conditions where the immune system attacks its own cells, such as lupus or rheumatoid arthritis.

• After severe blood loss, while the platelet count decreases, the size of the platelets can also be affected.

• Chemotherapy drugs and some blood-thinning medications can suppress platelet production.

• Vitamin B12 or folic acid deficiency can hinder the healthy production of platelets.

Low MPV is usually detected during routine blood tests. However, more detailed tests may be needed to understand the cause of this condition:

1. Complete Blood Count (CBC): Platelet count and MPV measurement are performed.

2. Bone Marrow Biopsy: Applied when bone marrow problems are suspected.

3. Vitamin and Mineral Levels: B12, folic acid, and iron levels are evaluated.

4. Infection Tests: The presence of viral or bacterial infections is investigated.

Low MPV is generally not a symptom on its own but may indicate an underlying health problem. However, some people may experience the following symptoms related to low MPV:

• Fatigue
• Pale skin
• Dizziness
• Shortness of breath
• Headache
• Bleeding Problems: Easy bruising on the skin, nosebleeds, or gum bleeding.
• Fatigue and Weakness: Especially in conditions related to anemia.
• Susceptibility to Infection: Frequent infections if the immune system is weakened.
• Skin Rash or Pinpoint Bleeding: Small red spots under the skin called petechiae.

• Balanced Nutrition: Consume foods rich in iron, folic acid, and B12.
  •  Examples: Red meat, spinach, eggs, dairy products.
• Protection from Infections: Support your immune system by following hygiene rules.
• Reduce Stress: Chronic stress can negatively affect immunity and platelet production.
• Routine Check-ups: Have your blood values checked regularly to ensure early diagnosis of potential issues.

Low MPV itself is not a condition that requires direct treatment, but the underlying cause should be treated. Treating the disease causing low MPV may help return MPV levels to normal. Therefore, when diagnosed with low MPV, your doctor may perform additional tests to identify the underlying cause and recommend appropriate treatment.

Treatment of low MPV depends on the underlying cause. For example:

• Bone Marrow Problems: Treatments such as chemotherapy, radiotherapy, or stem cell transplantation may be required.
• Vitamin Deficiencies: Treatment with B12 vitamin, folic acid, or iron supplements.
• Autoimmune Diseases: Immunosuppressive drugs may be used.
• Inflammatory Conditions: Inflammation is controlled with anti-inflammatory medications.

Some measures you can take to prevent low MPV are:

• Following a balanced diet
• Exercising regularly
• Quitting smoking and alcohol consumption
• Paying attention to stress management
• Going to regular doctor check-ups